Proposta é hiperestimular o mecanismo de divisão celular descontrolada; com isso, célula tumoral fica desestabilizada e é levada à morte
Usar o principal defeito das células de câncer contra elas: essa é uma estratégia descoberta no Instituto Butantan que pode ajudar no desenvolvimento de novas terapias contra a doença no futuro. Ao contrário das terapias convencionais, a proposta é hiperestimular o mecanismo de divisão celular descontrolada e, ao mesmo tempo, inibir as vias que regulam o estresse (a sobrecarga que a própria divisão causa na célula). Com isso, a célula tumoral fica desestabilizada e é levada à morte.
A tecnologia foi validada em um estudo publicado recentemente na revista Cancer Discovery pelo biomédico Matheus Henrique Dias, que começou a investigar a abordagem durante seu doutorado e pós-doutorado no Laboratório de Ciclo Celular do Butantan, sob orientação do pesquisador científico Hugo Armelin. Hoje, Matheus dá continuidade ao seu pós-doutorado no Instituto Holandês do Câncer, em Amsterdã.
Os resultados mostraram que o tratamento é altamente letal e específico para células cancerígenas, sendo capaz de reduzir tumores em modelos animais de câncer colorretal sem afetar células saudáveis.
Tradicionalmente, as terapias contra o câncer tentam inibir a proliferação descontrolada das células. O problema é que as células malignas possuem vários mecanismos para contornar os tratamentos e podem acabar desenvolvendo resistência. “Além disso, drogas quimioterápicas atacam todas as células que se dividem muito rapidamente, incluindo as saudáveis, resultando nos efeitos colaterais que conhecemos”, explica Matheus.
Pensando nisso, o estudo tentou fazer o oposto, sobrecarregando as células tumorais. Como elas já possuem naturalmente um nível de estresse muito mais elevado do que as células saudáveis, quando são hiperestimuladas e não têm acesso aos mecanismos de controle desse estresse, acabam morrendo.
“É como se a célula tumoral fosse um carro em alta velocidade. Em vez de tentar parar o carro, o que estamos fazendo é acelerar ainda mais e, ao mesmo tempo, desligar o sistema de resfriamento do motor”, diz o biomédico.
Outra vantagem observada no estudo é que as células tumorais que desenvolviam resistência, apesar de não morrerem, acabavam se tornando menos malignas, ou seja, incapazes de gerar um tumor. A crescente resistência de alguns tipos de câncer aos quimioterápicos é um dos fatores que leva os cientistas a buscarem novas formas de combater a doença.
O vídeo abaixo mostra como é a divisão das células de câncer e como esse processo é afetado após a terapia experimental:
Por dentro da tecnologia
O ponto de partida foi um artigo publicado em 2019 na Molecular Oncology, no qual a equipe do Butantan demonstrou que o fator de crescimento FGF2, descoberto por Hugo Armelin em 1973, gera um grande estresse para a célula de câncer ao estimular a via mitogênica (que induz a mitose, isto é, a divisão celular). Quando associado a um quimioterápico, o estresse se tornava insuportável e a célula tumoral morria.
“Ao serem estimuladas para se multiplicar, as células de câncer vão se afundando em um estresse que só é controlado porque elas têm meios de ativar as vias de regulação. Aí o truque passou a ser claro para nós: juntar a estimulação do crescimento com um inibidor do mecanismo de controle do estresse para sobrecarregar o tumor”, afirma Hugo Armelin.
No estudo atual, para combinar os dois efeitos, foram utilizados dois fármacos experimentais para inibir as proteínas PP2A e WEE1, que atuam nas vias de interesse. Mais de 160 moléculas foram testadas para encontrar a combinação mais eficaz. As moléculas selecionadas já foram avaliadas separadamente em ensaios clínicos e se mostraram seguras.
Outra combinação de moléculas está sendo testada no Butantan, como parte do doutorado do biomédico Thompson Torres, e deve ter os resultados publicados em breve. O grupo liderado por Hugo Armelin também faz experimentos com outras linhagens de câncer para verificar como diferentes tipos da doença se comportam frente à terapia. Resultados positivos já foram obtidos contra um tumor de mama triplo negativo, um dos tipos mais agressivos.
Siga o canal “Governo de São Paulo” no WhatsApp:
https://bit.ly/govspnozap
Профессиональные seo https://seo-optimizaciya-kazan.ru услуги для максимизации онлайн-видимости вашего бизнеса. Наши эксперты проведут глубокий анализ сайта, оптимизируют контент и структуру, улучшат технические аспекты и разработают индивидуальные стратегии продвижения.
1xbet https://1xbet.best-casino-ar.com with withdrawal without commission. Register online in a few clicks. A large selection of slot machines in mobile applications and convenient transfers in just a few minutes.
Buy TikTok followers https://tiktok-followers-buy.com to get popular and viral with your content. All packages are real and cheap — instant delivery within minutes. HQ followers for your TikTok. 100% real users. The lowest price for TikTok followers on the market
Pin-up casino https://pin-up.jes-design.ru популярное онлайн-казино и ставки на спорт. Официальный сайт казино для доступа к играм и другим функциям казино для игры на деньги.
Официальный сайт Pin Up казино https://pin-up.nasledie-smolensk.ru предлагает широкий выбор игр и щедрые бонусы для игроков. Уникальные бонусные предложения, онлайн регистрация.
Azerbaijan NFL https://nfl.com.az News, analysis and topics about the latest experience, victories and records. A portal where the most beautiful NFL games in the world are generally studied.
Discover exciting virtual football in Fortnite https://fortnite.com.az. Your central hub for the latest news, expert strategies and interesting e-sports reports. Collecting points with us!
The latest analysis, tournament reviews and the most interesting features of the Spider-Man game https://spider-man.com.az series in Azerbaijani.
Explore the extraordinary journey of Kilian Mbappe https://kilian-mbappe.com.az, from his humble beginnings to global stardom. Delve into his early years, meteoric rise through the ranks, and impact on and off the football field.
Mesut Ozil https://mesut-ozil.com.az latest news, statistics, photos and much more. Get the latest news and information about one of the best football players Mesut Ozil.
Paul Labille Pogba https://paul-pogba.psg-fr.com Footballeur francais, milieu de terrain central du club italien de la Juventus. Champion du monde 2018. Actuellement suspendu pour dopage et incapable de jouer.
Mohamed Salah Hamed Mehrez Ghali https://mohamed-salah.liverpool-fr.com Footballeur egyptien, attaquant du club anglais de Liverpool et l’equipe nationale egyptienne. Considere comme l’un des meilleurs joueurs du monde.
Kevin De Bruyne https://liverpool.kevin-de-bruyne-fr.com Belgian footballer, born 28 June 1991 years in Ghent. He has had a brilliant club career and also plays for the Belgium national team. De Bruyne is known for his spectacular goals and brilliant assists.
Kylian Mbappe https://psg.kylian-mbappe-fr.com Footballeur, attaquant francais. L’attaquant de l’equipe de France Kylian Mbappe a longtemps refuse de signer un nouveau contrat avec le PSG, l’accord etant en vigueur jusqu’a l’ete 2022.
Latest news and information about Marcelo https://marcelo.com.az on this site! Find Marcelo’s biography, career, playing stats and more. Find out the latest information about football master Marcelo with us!
Khabib Abdulmanapovich Nurmagomedov https://khabib-nurmagomedov.com.az Russian mixed martial arts fighter who performed under the auspices of the UFC. Former UFC lightweight champion.
Welcome to the site dedicated to Michael Jordan https://michael-jordan.com.az, a basketball legend and symbol of world sports culture. Here you will find highlights, career, family and news about one of the greatest athletes of all time.
Diego Armando Maradona https://diego-maradona.com.az Argentine footballer who played as an attacking midfielder and striker. He played for the clubs Argentinos Juniors, Boca Juniors, Barcelona, ??Napoli, and Sevilla.
Usain St. Leo Bolt https://usain-bolt.com.az Jamaican track and field athlete, specialized in short-distance running, eight-time Olympic champion and 11-time world champion (a record in the history of this competition among men).
Latest news and information about the NBA https://basketball-kz.kz in Kazakhstan. Hot stories, player transfers and highlights. Watch the NBA world with us.
Latest news about games for Android https://android-games.kz, reviews and daily updates. Read now and get the latest information about the most exciting games
Latest news and analysis of the Premier League https://premier-league.kz. Full descriptions of matches, team statistics and the most interesting football events. Premier Kazakhstan is the best place for football fans.
Зеркала интерьерные https://zerkala-mag.ru в интернет-магазине «Зеркала с подсветкой» Самые низкие цены на зеркала!
Предлагаем купить гаражное оборудование https://profcomplex.pro, автохимию, технику и уборочный инвентарь для клининговых компаний. Доставка по Москве и другим городам России.
Купить зеркала https://zerkala-m.ru по низким ценам. Более 1980 моделей, купить недорого в интернет-магазине в Москве с доставкой по России. Удобный каталог, низкие цены, качественные фото.
Spider-Man https://spiderman.kz the latest news, articles, reviews, dates, spoilers and other latest information. All materials on the topic “Spider-Man”
Latest Counter-Strike 2 news https://counter-strike-kz.kz, watch the most successful tournaments and be the best in the gaming world.
UFC news https://ufc-ar.com, schedule of fights and tournaments 2024, ratings of UFC fighters, interviews, photos and videos. Live broadcasts and broadcasts of tournaments, statistics, forums and fan blogs.
The most important sports news https://bein-sport-egypt.com, photos and blogs from experts and famous athletes, as well as statistics and information about matches of leading leagues.
News and events of the American Basketball League https://basketball-eg.com in Egypt. Hot events, player transfers and the most interesting events. Explore the world of the NBA with us.
News, tournaments, guides and strategies about the latest GTA games https://gta-ar.com. Stay tuned for the best GTA gaming experience
The path of 21-year-old Jude Bellingham https://realmadrid.jude-bellingham-cz.com from young talent to one of the most promising players in the world, reaching new heights with Dortmund and England.
Lionel Messi https://intermiami.lionel-messi-cz.com, one of the best football players of all time, moves to Inter Miami” and changes the face of North American football.
Bernardo Mota Veiga de Carvalho e Silva https://manchestercity.bernardo-silva-cz.com Portuguese footballer, club midfielder Manchester City and the Portuguese national team.
Antoine Griezmann https://atlticomadrid-dhb.antoine-griezmann-cz.com Atletico Madrid star whose talent and decisive goals helped the club reach the top of La Liga and the UEFA Champions League.
We explore the path of Luka Modric https://realmadrid.luka-modric-cz.com to Real Madrid, from a difficult adaptation to legendary Champions League triumphs and personal awards.
The impact of the arrival of Cristiano Ronaldo https://annasr.cristiano-ronaldo-cz.com at Al-Nasr. From sporting triumphs to cultural changes in Saudi football.
Find out how Pedri https://barcelona.pedri-cz.com becomes a key figure for Barcelona – his development, influence and ambitions determine the club’s future success in world football.
r7 casino войти https://mabiclub.ru
buy instagram likes buy instagram views
Find out how Bruno Guimaraes https://newcastleunited.bruno-guimaraes-cz.com became a catalyst for the success of Newcastle United thanks to his technical abilities and leadership on the field and beyond.
Study of the playing style of Toni Kroos https://real-madrid.toni-kroos-cz.com at Real Madrid: his accurate passing, tactical flexibility and influence on the team’s success.
Romelu Lukaku https://chelsea.romelu-lukaku-cz.com, one of the best strikers in Europe, returns to Chelsea to continue climbing to the top of the football Olympus.
The story of how the incredibly talented footballer Riyad Mahrez https://alahli.riyad-mahrez-cz.com reached new heights in career, moving to Al Ahly and leading the team to victory.
The fascinating story of Antonio Rudiger’s transfer https://real-madrid.antonio-rudiger-cz.com to Real Madrid and his rapid rise as a key player at one of the best clubs in the world.
Try to make a fascinating actor Johnny Depp https://secret-window.johnny-depp.cz, who will become the slave of his strong hero Moudriho Creeps in the thriller “Secret Window”.
The legendary Spanish racer Fernando Alonso https://formula-1.fernando-alonso.cz returns to Formula 1 after several years.
Free movies https://www.moviesjoy.cc and TV streaming online, watch movies online in HD 1080p.
NFL https://nfl-ar.com News, analysis and topics about the latest practices, victories and records. A portal that explores the most beautiful games in the NFL world in general.
Discover the wonderful world of online games https://onlayn-oyinlar.com with GameHub. Get the latest news, reviews and tips for your favorite games. Join our gaming community today!
Sports news https://gta-uzbek.com the most respected sports site in Uzbekistan, which contains the latest sports news, forecasts and analysis.
Find the latest information on Khabib Nurmagomedov https://khabib-nurmagomedov.uz news and fights. Check out articles and videos detailing Khabib UFC career, interviews, wins, and biography.
Discover how Riyad Mahrez https://al-ahli.riyad-mahrez.com transformed Al-Ahli, becoming a key player and catalyst in reaching new heights in world football.
Gavi’s success story https://barcelona.gavi-fr.com at Barcelona: from his debut at 16 to a key role in club and national team of Spain, his talent inspires the world of football.
The story of the Moroccan footballer https://al-hilal.yassine-bounou.com, who became a star at Al-Hilal, traces his journey from the streets of Casablanca to international football stardom and his personal development.
Del Mar Energy Company is an international industrial holding company engaged in the extraction of oil, gas, and coal
The story of the great Kobe Bryant https://los-angeles-lakers.kobe-bryant-fr.com with ” Los Angeles Lakers: his path to the championship, his legendary achievements.
Novak Djokovic’s https://tennis.novak-djokovic-fr.biz journey from childhood to the top of world tennis: early years, first victories, dominance and influence on the sport.
The story of Fernando Alonso https://formula-1.fernando-alonso-fr.com in Formula 1: a unique path to success through talent, tenacity and strategic decisions, inspiring and exciting.
Max Verstappen and Red Bull Racing’s https://red-bull-racing.max-verstappen-fr.com path to success in Formula 1. A story of talent, determination and team support leading to a championship title.
Parisian PSG https://paris.psg-fr.com is one of the most successful and ambitious football clubs in Europe. Find out how he became a global football superstar.
air montenegro Visit Montenegro
The iconic Anfield https://enfield.liverpool-fr.com stadium and the passionate Liverpool fans are an integral part of English football culture.
Преимущества аренды склада https://vyvozmusorascherbinka.ru/preimushhestva-arendy-sklada-kak-optimizirovat-biznes-proczessy-i-snizit-izderzhki/, как аренда складских помещений может улучшить ваш бизнес
The fascinating story of the phenomenal rise and meteoric fall of Diego Maradona https://napoli.diegomaradona.biz, who became a cult figure at Napoli in the 1980s.
Cristiano Ronaldo https://al-nassr.cristianoronaldo-br.net one of the greatest football players of all time, begins a new chapter in his career by joining An Nasr Club.
The fascinating story of Marcus Rashford’s rise https://manchester-united.marcusrashford-br.com from academy youth to the main striker and captain of Manchester United. Read about his meteoric rise and colorful career.
RioBet https://bookparts.ru
Хотите научиться готовить самые изысканные и сложные торты? В этом https://v1.skladchik.org/tags/tort/ разделе вы найдете множество подробных пошаговых рецептов самых трендовых и известных тортов с возможностью получить их за сущие копейки благодаря складчине. Готовьте с удовольствием и открывайте для себя новые рецепты вместе с Skladchik.org
Лучшие пансионаты для пожилых людей https://ernst-neizvestniy.ru в Самаре – недорогие дома для престарелых в Самарской области
Brazilian footballer Malcom https://al-hilal.malcom-ar.com (full name Malcom Felipe Silva de Oliveira) achieved great success in Al Hilal, one of the leading football teams in Saudi Arabia and the entire Middle East.
Travis Scott https://astroworld.travis-scott-ar.com is one of the brightest stars in the modern hip-hop industry.
Chelsea https://england.chelsea-ar.com is one of the most successful English football clubs of our time.
купить новую квартиру в новостройке https://kvartira-new43.ru
квартира в новостройке от застройщика купить квартиру в новостройке недорого
купить новостройку в ипотеку купить новую квартиру застройщик
Заказать дипломную работу https://diplomzakazat-oline.ru недорого. Дипломные работы на заказ с гарантией.
продвижение сайта в поисковых системах https://seo-raskrutka43.ru
продвижение сайта в поисковых системах раскрутка сайта цена
Новини, останні події https://prp.org.ua в Україні та світі, новини політики, бізнесу та економіки, законодавства
Головні новини https://status.net.ua сьогодні, найсвіжіші та останні новини України онлайн
Автомобільний портал https://autodream.com.ua новини та огляди новинок авторинку.
Щоденні новини https://autoinfo.kyiv.ua із автомобільного середовища. Поради автоаматорам. Тест-драйви
Автомобільні новини https://avtonews.kyiv.ua України. Все для автовласника.
DMV Test на русском языке https://papadmv.com тесты с ответами ПДД США 2024. Тренировочные dmv test на русском для сдачи на права, изучите правила дорожного движения США для разных штатов.
Undress AI & Bulk Nude AI Generator https://nudifyonline.vip. Make AI nudes and bulk generate undress AI photos of any girl for almost free!
Щоденні новини https://k-moto.com.ua із автомобільного середовища. Поради автоаматорам. Тест-драйви автомобілів з пробігом та огляди новинок
вывод из запоя стационар (вывода из запоя в стационаре) [url=http://vyvod-iz-zapoya-sochi11.ru]вывод из запоя стационар (вывода из запоя в стационаре)[/url] .